| Rank | Movie | Number of Screens | Gross | Year |
|---|
| 1 | Kabali (Tamil/Telugu) 24 Days | 240 | $4,157,234 | 2016 |
| 2 | Endhiran (Tamil Only) | 64 | $1,520,108 | 2010 |
| Endhiran (Telugu Only) | 36 | $614,077
| 2010 |
| Robot (Hindi Only) | 39 | $274,639 | 2010 |
| Endhiran (Tamil/Hindi/Telugu) | 139 | $2,408,824 | 2010 |
| 3 | Lingaa (Tamil/Telugu) | 135 | $1,514,298 | 2014 |
| 4 | 24 (Tamil/Telugu) | 155 | $1,470,761 | 2016 |
| 5 | Sivaji | - | $1,300,000~ | 2007 |
| 6 | Vishwaroopam (Tamil Only) | 44 | $1,039,994 | 2013 |
| Vishwaroopam (Telugu Only) | 28 | $200,293 | 2013 |
| Vishwaroopam (Tamil/Telugu) | 72 | $1,240,287 | 2013 |
| 7 | I (Tamil Only) | 154 | $797,204 | 2010 |
| I (Telugu Only) | 131 | $486,906 | 2010 |
| I (Hindi Only) | 36 | $28,889 | 2010 |
| I (Tamil/Hindi/Telugu) | 321 | $1,312,999 | 2010 |
| 8 | Dasavatharam | - | $750,000~ | 2008 |
| 9 | Theri | 135 | $729,366 | 2016 |
| 10 | OK Kanmani [Tamil] | 65 | $714,334 | 2015 |
| OK Bangaram [Telugu] | 39 | $358,983 | 2015 |
| OK Kanmani [Tamil/Telugu] | 104 | $1,073,317 | 2015 |
| 11 | Kochadaiiyaan [Tamil] | 104 | $635,000 | 2014 |
| Kochadaiiyaan [Hindi] | 4 | $16,193 | 2014 |
| Kochadaiiyaan [Telugu] | 68 | $15,000 | 2014 |
| Kochadaiiyaan [Tamil/Telugu/Hindi] | 176 | $666,193 | 2014 |
| 12 | Baahubali [Tamil] | 66 | $632,603 | 2015 |
| 13 | Kaththi | 98 | $622,114 | 2014 |
| 14 | Uttama Villain (Tamil Only) | 98 | $585,052 | 2015 |
| Uttama Villain (Telugu Only) | 33 | $57,249 | 2015 |
| Uttama Villain (Tamil/Telugu) | 131 | $642,301 | 2015 |
| 15 | Yennai Arindhaal | 98 | $515,629 | 2015 |
| 16 | Thoongavanam | 80 | $469,337 | 2015 |
| 17 | Arrambam | 75 | $380,141 | 2013 |
| 18 | Thuppakki | 36 | $364,000 | 2012 |
| 19 | 7 am Arivu | 61 | $325,898 | 2011 |
| 20 | Singam II | 46 | $318,200 | 2013 |
| 21 | Manmathan Anbu | - | $318,000 | 2010 |
| 22 | Papanasam | 80 | $306,152 | 2015 |
| 23 | Thani Oruvan | 33 | $297,772 | 2015 |
| 24 | Vedalam | 71 | $288,071 | 2015 |
| 25 | Masss | 34 | $264,411 | 2015 |
| Masss (Telugu Only) | 23 | $39,200 | 2015 |
| Masss (Tamil/Telugu) | 23 | $303,611 | 2015 |
| 26 | Thalaivaa | 70 | $259,000 | 2013 |
| 27 | Naanum Rowdy Dhaan | 34 | $259,276 | 2015 |
| 28 | Veeram | 69 | $243,955 | 2014 |
| 29 | Mankatha | 29 | $241,441 | 2011 |
| 30 | Raja Rani | 34 | $232,443 | 2013 |
| 31 | Jilla | 71 | $230,221 | 2014 |
| 32 | Nanban | 50 | $209,147 | 2012 |
| 33 | Vellai Illa Pattathari | 30 | $224,195 | 2014 |
| 34 | Jigarthanda | 20 | $195,073 | 2014 |
| 35 | Puli | 90 | $192,007 | 2015 |
| Puli [Telugu] | 16 | $2,854 | 2015 |
| 36 | Thaandavam | 21 | $183,661 | 2012 |
| 37 | Mattrraan | - | $181,936 | 2012 |
| 38 | Anjaan | 57 | $182,007 | 2014 |
| 39 | Anegan | 45 | $134,128 | 2015 |
| 40 | Billa 2 | 61 | $131,640 | 2012 |
| 41 | Biriyai | 35 | $125,500 | 2013 |
| 42 | Deiva Thirumagal | 22 | $104,000 | 2011 |
| 43 | Neethaane Ponvasantham | - | $92,102 | 2013 |
| 44 | Maari | 40 | $89,176 | 2015 |
| 45 | Velayudam | - | $83,269 | 2011 |
| 46 | Madras | 34 | $81,358 | 2014 |
| 47 | Avan Ivan | 18 | $81,100 | 2011 |
| 48 | Mariyan | 21 | $78,459 | 2013 |
| 49 | 36 Vayadhinile | 32 | $76,578 | 2015 |
| 50 | MaanKarate | 30 | $73,015 | 2014 |
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